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Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment | |
Koivisto, AJ (Koivisto, Antti J.)[ 1 ]; Palomaki, JE (Palomaki, Jaana E.)[ 1 ]; Viitanen, AK (Viitanen, Anna-Kaisa)[ 1 ]; Siivola, KM (Siivola, Kirsi M.)[ 1 ]; Koponen, IK (Koponen, Ismo K.)[ 2 ]; Yu, MZ (Yu, Mingzhou)[ 3 ]; Kanerva, TS (Kanerva, Tomi S.)[ 1 ]; Norppa, H (Norppa, Hannu)[ 1 ]; Alenius, HT (Alenius, Harri T.)[ 1 ]; Hussein, T (Hussein, Tareq)[ 4,5 ]; Savolainen, KM (Savolainen, Kai M.)[ 1 ]; Hameri, KJ (Hameri, Kaarle J.)[ 5 ] | |
2014-05-15 | |
发表期刊 | INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH |
卷号 | 11期号:5页码:5382-5402 |
文章类型 | 期刊论文 |
摘要 | This study considers fundamental methods in occupational risk assessment of exposure to airborne engineered nanomaterials. We discuss characterization of particle emissions, exposure assessment, hazard assessment with in vitro studies, and risk range characterization using calculated inhaled doses and dose-response translated to humans from in vitro studies. Here, the methods were utilized to assess workers' risk range of inhalation exposure to nanodiamonds (NDs) during handling and sieving of ND powder. NDs were agglomerated to over 500 nm particles, and mean exposure levels of different work tasks varied from 0.24 to 4.96 mu g.m(-3) (0.08 to 0.74 cm(-3)). In vitro-experiments suggested that ND exposure may cause a risk for activation of inflammatory cascade. However, risk range characterization based on in vitro dose-response was not performed because accurate assessment of delivered (settled) dose on the cells was not possible. Comparison of ND exposure with common pollutants revealed that ND exposure was below 5 mu g.m(-3), which is one of the proposed exposure limits for diesel particulate matter, and the workers' calculated dose of NDs during the measurement day was 74 ng which corresponded to 0.02% of the modeled daily (24 h) dose of submicrometer urban air particles. |
关键词 | Nanomaterial Occupational Hygiene Source Characterization Exposure Assessment Dose Assessment In Vitro |
DOI | 10.3390/ijerph110505382 |
收录类别 | SCIE |
语种 | 英语 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.ieecas.cn/handle/361006/9735 |
专题 | 黄土与第四纪地质国家重点实验室(2010~) |
通讯作者 | Koivisto, AJ (Koivisto, Antti J.)[ 1 ] |
作者单位 | 1.Nanosafety Research Centre, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A,FI-00250 Helsinki, Finland; 2.National Research Centre for the Working Environment, Lersø Parkallé 105, Copenhagen DK-2100,Denmark; 3.Institute of Earth Environment, Chinese Academy of Sciences, Fenghui Road, Xi’an 710075,China; 4.Department of Physics, Faculty of Science, The University of Jordan, Amman JO-11942, Jordan; 5.Department of Physics, University of Helsinki, Gustaf Hällströmin Katu 2, P.O. Box 64, HelsinkiFI-00014, Finland |
推荐引用方式 GB/T 7714 | Koivisto, AJ ,Palomaki, JE ,Viitanen, AK ,et al. Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,2014,11(5):5382-5402. |
APA | Koivisto, AJ .,Palomaki, JE .,Viitanen, AK .,Siivola, KM .,Koponen, IK .,...&Hameri, KJ .(2014).Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,11(5),5382-5402. |
MLA | Koivisto, AJ ,et al."Range-Finding Risk Assessment of Inhalation Exposure to Nanodiamonds in a Laboratory Environment".INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 11.5(2014):5382-5402. |
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文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | ||
Range-Finding Risk A(1079KB) | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | 请求全文 |
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